The Influence of the Greek Technique of Tragedy in the Works of Eugene O'Neill

Thesis (M.A.)--Boston University, 1945. This item was digitized by the Internet Archive

Smoothing T cell roads to the tumor: Chemokine post-translational regulation

We described a novel tumor-associated immunosuppressive mechanism based on post-translational modifications of chemokines by reactive nitrogen species (RNS). To overcome tumor immunosuppressive hindrances, we designed and developed a new drug, AT38, that inhibits RNS generation at the tumor site. Combinatorial approaches with AT38 boost the effectiveness of cancer immunotherapy protocols

Tuning cancer fate: the unremitting role of host immunity

Host immunity plays a central and complex role in dictating tumour progression. Solid tumours are commonly infiltrated by a large number of immune cells that dynamically interact with the surrounding microenvironment. At first, innate and adaptive immune cells successfully cooperate to eradicate microcolonies of transformed cells. Concomitantly, surviving tumour clones start to proliferate and harness immune responses by specifically hijacking anti-tumour effector mechanisms and fostering the accumulation of immunosuppressive immune cell subsets at the tumour site. This pliable interplay between immune and malignant cells is a relentless process that has been concisely organized in three different phases: elimination, equilibrium and escape. In this review, we aim to depict the distinct immune cell subsets and immune-mediated responses characterizing the tumour landscape throughout the three interconnected phases. Importantly, the identification of key immune players and molecules involved in the dynamic crosstalk between tumour and immune system has been crucial for the introduction of reliable prognostic factors and effective therapeutic protocols against cancers

Teaching in groups in grade III.

Thesis (Ed.M.)--Boston University N.B.:Pages 28, 144 and 145 are missing from original thesis

Latin American perspectives and the IT2017 curricular guidelines

The term information technology has many meanings for various stakeholders and continues to evolve. This discussion presents an overview of the developing curricular guidelines for rigorous, high quality, bachelor\u27s degree programs in information technology (IT), called IT2017. Panel participants will focus on Latin American academic and industry perspectives on IT undergraduate education. Discussion will seek to ascertain commonalities and differences between the current draft IT2017 report and perspectives from Latino/a professional and academic communities. It also addresses ways in which this endeavor contrasts with current practices in Latin America industry and academia

Latin American perspectives to internationalize undergraduate information technology education

The computing education community expects modern curricular guidelines for information technology (IT) undergraduate degree programs by 2017. The authors of this work focus on eliciting and analyzing Latin American academic and industry perspectives on IT undergraduate education. The objective is to ensure that the IT curricular framework in the IT2017 report articulates the relationship between academic preparation and the work environment of IT graduates in light of current technological and educational trends in Latin America and elsewhere. Activities focus on soliciting and analyzing survey data collected from institutions and consortia in IT education and IT professional and educational societies in Latin America; these activities also include garnering the expertise of the authors. Findings show that IT degree programs are making progress in bridging the academic-industry gap, but more work remains

Herausforderungen qualitativer Interviewstudien innerhalb von Organisationen: methodologische Überlegungen zu einer empirischen Rekonstruktion schulischer Organisationen am Beispiel des Forschungsprojektes "Realisierung testbasierter Schulreform"

"In der empirischen Bildungsforschung rücken durch das Paradigma der neuen Steuerung schulische Organisationen als methodische Falleinheiten in den Fokus empirischer Untersuchungen. Dazu werden vor allem Interviewdaten als individuelle Aussagen aus unterschiedlichen Ebenen des Schulsystems bzw. Akteursperspektiven der Schule aggregiert. Bisher konnte nicht ausreichend geklärt werden, wie die Validität der Ergebnisse aus den Interviewstudien als empirische Abbildung der schulischen Organisationen zu bewerten ist. Neben der Erörterung der zuvor dargelegten Problemstellung werden im Artikel vor allem drei grundlegende Anforderungen eines Validitätskonzepts bei der empirischen Rekonstruktion von schulischen Organisationen diskutiert: a) Die Repräsentations-, b) die Mehrperspektiven-, c) die Mehrebenenthematik. Abschließend wird durch die Synthese einer systemtheoretischen und rekonstruktiven Organisationsforschung ein theoretisch- methodischer Lösungsansatz aufgezeigt, der diese Anforderungen in Rechnung stellt und zu einem empirisch-theoretischen Validitätsverständnis führt. Die Ausführungen des Beitrags können als grundlagentheoretische, methodologische Herausforderungen bei der empirischen Rekonstruktion von Organisationen - unabhängig vom konkreten Kontext bzw. Gegenstandsbereich - innerhalb der qualitativen Organisationsforschung aufgefasst werden. Die Grundlage der hier dargelegten Betrachtung bildet die vom BMBF geförderte Studie 'Die Realisierung testbasierter Schulreform in der Mehrebenenstruktur des Schulsystems', die als gegenstandsbezogene Darstellung der methodischen Herausforderungen herangezogen wird." (Autorenreferat)"Within the empirical educational research school organizations as methodical case units move into the focus of empirical investigations due to the paradigmatic shift of a new governance. Therefore, results from interview studies are aggregated including individual statements from different levels of the school system or from the stakeholder perspectives of the school itself. So far there is no sufficient clarification how the validity of these results can be interpreted as an empirical reproduction of the school organization. In addition to explaining the outlined problem, the article discusses three basic requirements of an validation concept regarding the empirical reconstruction of school organizations: the topic of a) the representativeness, b) a multi- perspective view and c) the multi-level approach. Finally, the synthesis of systemtheoretical and reconstructive organizational research demonstrates a theoreticalmethodological solution approach, which overcomes the mentioned deficits and leads to a validation concept. The empirical basis includes data from the qualitative study 'The Realization of the Test-Based School Reform' funded by the Federal Ministry ofEducation and Research: In a longitudinal design individual structured interviews about the use of mandatory tests were conducted with central actors on all levels of the educational system in four German federal states. The interview data was evaluated according to the qualitative content analysis." (author's abstract

Superhydrophobicity Due to the Hierarchical Scale Roughness of PDMS Surfaces

Wettability control has been widely investigated in the last decades for technological applications such as microfluidic devices and self-cleaning surfaces by modifying both the chemical composition and the geometric structure of the surfaces. Inspired by the typical morphology of superhydrophobic leaves (such as lotus leaves), we have developed a dual-scale roughness, micro- and nanosized, on polydimethylsiloxane (PDMS) surfaces. By combining different geometric parameters and plasma treatment conditions, the structures were controlled hierarchically, at different independent length scales. Both the microsized replicated pillars and the nanosized etched posts tuned the wettability of the PDMS surfaces in a very simple way, up to contact angles of 170°. Furthermore, changes in the influence of micro- and nanoscale geometrical structures were investigated. Hysteresis and contact angles of water droplets are evaluated as a combined effect of micropillars and a superimposed roughness, resulting in high advan..

Development of an innovative method to predict and to characterize the performances of Ti-6Al-4V LBW joints

Every manufacturing process leaves on the surface of the piece a typical "technology signature". In particular, the laser welding leaves a feature at the edge of the weld bead called "undercut". In this work an experimental campaign has been conducted on Ti6Al4V butt joints. In particular a Central Composite Design (CCD) with the central point repeated three times has been investigated. In the CCD there are two factors (power and speed of the fiber laser) and five levels for each factor. This paper deals with the investigation about the correlation between the severity of the undercut and the process parameters of the laser welding. In particular, through the confocal microscopy, the original geometry of the joint was accurately acquired and rebuilt in order to make a FEM model and simulate the mechanical behavior using Ansys14.5. Moreover, response surfaces and level curves were carried out to understand and predict the depth and the width of the undercut starting from the power and the speed of the laser. At last a mathematic and geometry regression was performed in order to find a unique conical curve that interpolates all the different undercuts and that varies its parameters according to the process parameters. It is established that the process with higher speed minimizes and optimizes the undercut in the joints

Engineering transfer of micro- and nanometer-scale features by surface energy modification.

Micropatterning of surfaces is gaining importance in various applications ranging from biosensors to microfluidic and lab-on-a-chip devices, where the control of the surface chemistry is of great importance for the application. In this paper, we introduce a patterning technique of topographical features, which is applicable on different substrates by modifying their surface energy. The textured surface is obtained via polydimethylsiloxane (PDMS) transfer, and the topographical parameters can be systematically tailored by selective treatment with oxygen plasma of either the PDMS stamp, the substrate, or both. Our approach is an alternative technique to create micro- and nanopatterns of various height and shape over a large area on different substrates. The possibility to control cell behavior on different surfaces tailored with this microtransfer patterning approach was also evaluated. The cell culture on patterned surfaces showed the possibility of modulating cell adhesion. Our method is based on simple transfer of silicone elastomeric patterns to the surface, and therefore, it is very simple and fast compared to other complex techniques. These observations could have implications for tissue-scaffold engineering science in areas such as microfluidic devices and control of cell adhesion